Frequency of seizures in the Alzheimer's disease spectrum

 
   Lead Investigator:    Jonathan Voeglein
   Institution      :    Department of Neurology LMU Munich and DZNE Munic
   E-Mail           :    jonathan.voeglein@med.uni-muenchen.de
   Proposal ID      :    711



   Proposal Description:
   Our specific aim for our proposed work with the NACC data set is to find out      whether there is a difference in frequency of seizures between individuals with   sporadic Alzheimer's disease (AD), presymptomatic sporadic Alzheimer's disease    (preAD), autosomal dominant Alzheimer's disease (ADAD), presymptomatic            autosomal dominant Alzheimer's disease (preADAD) and normal controls (nc). For    comparison with ADAD and preADAD publications and data derived from the DIAN      observational study are planned to be included. We hypothesize that subjects in   a state of the Alzheimer's disease spectrum (AD, preAD, ADAD and preADAD) show    a higher frequency of seizures than normal controls. In particular in context     of many diverging evidence regarding seizures in the AD spectrum we seek to       unveil correlations and potentially substantiate the suspicion of a causal        connection of the different states of the AD spectrum with the vulnerability      for seizures. This knowledge might be considered for treatment decisions          regarding seizures in AD.